Pub. Date : 2020 Jun 26
PMID : 32458971
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acetate promotes SNAI1 expression by ACSS2-mediated histone acetylation under glucose limitation in renal cell carcinoma cell. | Acetates | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 2 | In this study, we first measured the effect of acetate on zinc finger transcriptional repressor SNAI1 and acetyl-CoA synthetase 2 (ACSS2) under glucose limitation in renal cell carcinoma cell lines 786-O and ACHN. | Acetates | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 3 | In this study, we first measured the effect of acetate on zinc finger transcriptional repressor SNAI1 and acetyl-CoA synthetase 2 (ACSS2) under glucose limitation in renal cell carcinoma cell lines 786-O and ACHN. | Acetates | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 4 | The results showed that acetate increased the expressions of SNAI1 and ACSS2 under glucose limitation. | Acetates | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 5 | ACSS2 knockdown significantly decreased acetate-induced SNAI1 expression and cell migration, whereas overexpression of ACSS2 increased SNAI1 level and histone H3K27 acetylation (H3K27ac). | Acetates | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 6 | Our study identified a novel inducer, acetate, which can promote SNAI1 expression by ACSS2 mediated histone acetylation in partly. | Acetates | acyl-CoA synthetase short chain family member 2 | Homo sapiens |