Pub. Date : 2020 Apr
PMID : 32420164
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Background: Combining testosterone and phosphodiesterase 5 inhibitors (PDE5-Is) has become increasingly common in the treatment of men with erectile dysfunction (ED) and low testosterone levels, but combination therapy involving PDE5-Is and testosterone is highly debated, with strong reasons for and against argued by the various opinion leaders. | Testosterone | phosphodiesterase 5A | Homo sapiens |
| 2 | Background: Combining testosterone and phosphodiesterase 5 inhibitors (PDE5-Is) has become increasingly common in the treatment of men with erectile dysfunction (ED) and low testosterone levels, but combination therapy involving PDE5-Is and testosterone is highly debated, with strong reasons for and against argued by the various opinion leaders. | Testosterone | phosphodiesterase 5A | Homo sapiens |
| 3 | Background: Combining testosterone and phosphodiesterase 5 inhibitors (PDE5-Is) has become increasingly common in the treatment of men with erectile dysfunction (ED) and low testosterone levels, but combination therapy involving PDE5-Is and testosterone is highly debated, with strong reasons for and against argued by the various opinion leaders. | Testosterone | phosphodiesterase 5A | Homo sapiens |
| 4 | PDE5-Is can be given prior to, alongside or after the commencement of any testosterone replacement therapy. | Testosterone | phosphodiesterase 5A | Homo sapiens |
| 5 | Meanwhile, combination of PDE5-Is and testosterone is reported to better increase testosterone levels and thus improve International Index of Erectile Function (IIEF) score in hypogonadal men. | Testosterone | phosphodiesterase 5A | Homo sapiens |
| 6 | The objective of this meta-analysis was to assess whether testosterone therapy (TTh) can possibly enhance the reaction to PDE5-Is in men with ED and hypogonadism. | Testosterone | phosphodiesterase 5A | Homo sapiens |