Title : Wogonoside inhibits inflammatory cytokine production in lipopolysaccharide-stimulated macrophage by suppressing the activation of the JNK/c-Jun signaling pathway.

Pub. Date : 2020 Apr

PMID : 32411755






2 Functional Relationships(s)
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1 Results: In this study, we found that pre-treatment with wogonoside dramatically suppressed lipopolysaccharide (LPS)-induced increase in the protein and mRNA levels of inflammatory factors in macrophages, such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6. wogonoside interleukin 1 alpha Homo sapiens
2 Additionally, ChIP analysis demonstrated wogonoside to remarkably reduce c-Jun enrichment in COX-2, iNOS, IL-1beta, TNF-alpha, and IL-6 promoters. wogonoside interleukin 1 alpha Homo sapiens