Title : GPR120 facilitates cholesterol efflux in macrophages through activation of AMPK signaling pathway.

Pub. Date : 2020 Dec

PMID : 32243091






2 Functional Relationships(s)
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1 In this study, we found for the first time that stimulation of GPR120 by its agonist GW9508 elevated the expression of ATP-binding cassette transporters (ABC) A1 and ABCG1 in THP-1 macrophage-derived foam cells and Raw264.7 macrophages, and promoted ABCA1- and ABCG1-mediated cholesterol efflux and reduced cellular cholesteryl ester content as well. GW9508 ATP binding cassette subfamily A member 1 Homo sapiens
2 In this study, we found for the first time that stimulation of GPR120 by its agonist GW9508 elevated the expression of ATP-binding cassette transporters (ABC) A1 and ABCG1 in THP-1 macrophage-derived foam cells and Raw264.7 macrophages, and promoted ABCA1- and ABCG1-mediated cholesterol efflux and reduced cellular cholesteryl ester content as well. GW9508 ATP binding cassette subfamily A member 1 Homo sapiens