CPRiL

ABCA1

ATP binding cassette subfamily A member 1

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019]

• phospholipid-transporting ATPase ABCA1
• ATP-binding cassette sub-family A member 1
• ATP-binding cassette transporter A1
ATP-binding cassette, sub-family A (ABC1), member 1
cholesterol efflux regulatory protein
membrane-bound
ABC-1
ABC1
CERP
HDLCQTL13
HDLDT1
HPALP1
TGD