Title : Molecular, histological and behavioral evidences for neuroprotective effects of minocycline against nicotine-induced neurodegeneration and cognition impairment: Possible role of CREB-BDNF signaling pathway.

Pub. Date : 2020 May 27

PMID : 32198107






2 Functional Relationships(s)
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1 In addition, nicotine treatment increased lipid peroxidation and the levels of oxidized form of glutathione (GSSG), interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and Bax protein, while decreasing reduced form of glutathione (GSH), Bcl-2 protein, P-CREB and BDNF levels in the hippocampus of experimental animals. Nicotine brain-derived neurotrophic factor Rattus norvegicus
2 CONCLUSION: It can be concluded that minocycline, probably through activation of P-CREB/BDNF signaling pathway, confers neuroprotection against nicotine-induced neurodegeneration in rat hippocampus. Nicotine brain-derived neurotrophic factor Rattus norvegicus