| Protein Name | brain-derived neurotrophic factor |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24225 |
| Gene Symbol | Bdnf |
| UniProt | P23363 (BDNF_RAT), A0A0G2K624 (A0A0G2K624_RAT), A0A0H2UI28 (A0A0H2UI28_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
1357
Total Number of Articles : 2991 |
Description |
brain-derived neurotrophic factor |
| Gene Summary |
Enables neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; neuron projection development; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and secretory vesicle. Used to study several diseases, including alcohol dependence; cocaine dependence; neuropathy (multiple); status epilepticus; and transient cerebral ischemia. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; brain disease (multiple); cognitive disorder (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; cocaine dependence; cognitive disorder (multiple); congenital central hypoventilation syndrome; and neurodegenerative disease (multiple). Orthologous to human BDNF (brain derived neurotrophic factor). [provided by Alliance of Genome Resources, Jun 2025] |
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