Title : Nitrous oxide and vitamin B12 in sickle cell disease: Not a laughing situation.

Pub. Date : 2020 Jun

PMID : 32195121






4 Functional Relationships(s)
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Protein Name
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1 N2O prolonged and recurrent administration is known to affect vitamin B12 metabolism with subsequent clinical consequences. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
2 We report herein the case of a 13-year-old girl with sickle cell disease exhibiting severe neurological and biochemical signs of functional vitamin B12 deficiency due to prolonged and repeated exposure to N2O. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
3 This was an incentive to prospectively investigate functional vitamin B12 deficiency in patients affected by sickle cell disease regularly exposed to N2O. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
4 The clinical case highlight the potential severe deleterious effects of N2O over exposure on B12 vitamin metabolism in particular in patients affected with sickle cell disease. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens