Title : TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.

Pub. Date : 2020 Mar 9

PMID : 32152270






1 Functional Relationships(s)
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Protein Name
Organism
1 A critical enzyme for TOP1cc resolution is the tyrosyl-DNA phosphodiesterase (TDP1), which hydrolyses the bond that links a tyrosine in the active site of TOP1 to a 3" phosphate group on a single-stranded (ss)DNA break. Tyrosine tyrosyl-DNA phosphodiesterase 1 Homo sapiens