Pub. Date : 2021 May
PMID : 32108308
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although nitrocatechol COMT inhibitors have been used in the treatment of Parkinson"s disease, efforts have been made to discover non-nitrocatechol inhibitors. | nitrocatechol | catechol-O-methyltransferase | Homo sapiens |
| 2 | In the present study, the 3-hydroxypyridin-4-one scaffold was selected for the design and synthesis of non-nitrocatechol COMT inhibitors since the COMT inhibitory potential of this class has been illustrated. | nitrocatechol | catechol-O-methyltransferase | Homo sapiens |
| 3 | Although these compounds are not highly potent inhibitors, they may act as leads for the development of non-nitrocatechol COMT inhibitors. | nitrocatechol | catechol-O-methyltransferase | Homo sapiens |