Title : α-Lipoic acid protects against microcystin-LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf2.

Pub. Date : 2020 Jul

PMID : 32061150






7 Functional Relationships(s)
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1 alpha-Lipoic acid protects against microcystin-LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf2. Thioctic Acid NFE2 like bZIP transcription factor 2 Homo sapiens
2 Alpha-lipoic acid (alpha-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Thioctic Acid NFE2 like bZIP transcription factor 2 Homo sapiens
3 Alpha-lipoic acid (alpha-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Thioctic Acid NFE2 like bZIP transcription factor 2 Homo sapiens
4 Alpha-lipoic acid (alpha-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Thioctic Acid NFE2 like bZIP transcription factor 2 Homo sapiens
5 Alpha-lipoic acid (alpha-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Thioctic Acid NFE2 like bZIP transcription factor 2 Homo sapiens
6 alpha-LA can mediate GSH regeneration through the Nrf2 pathway under the action of glutathione reductase in MC-LR cell lines. Thioctic Acid NFE2 like bZIP transcription factor 2 Homo sapiens
7 Furthermore, the data also showed that alpha-LA-induced cytoprotection against MC-LR is associated with Nrf2 mediate pathway in vivo. Thioctic Acid NFE2 like bZIP transcription factor 2 Homo sapiens