Title : Lidocaine attenuates lipopolysaccharide-induced inflammatory responses and protects against endotoxemia in mice by suppressing HIF1α-induced glycolysis.

Pub. Date : 2020 Mar

PMID : 31958741






4 Functional Relationships(s)
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1 In this study, we have shown that lidocaine dose-dependently inhibits lipopolysaccharide (LPS)-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in macrophages and that lidocaine protects mice from LPS-induced inflammation. Lidocaine interleukin 6 Mus musculus
2 In this study, we have shown that lidocaine dose-dependently inhibits lipopolysaccharide (LPS)-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in macrophages and that lidocaine protects mice from LPS-induced inflammation. Lidocaine interleukin 6 Mus musculus
3 In this study, we have shown that lidocaine dose-dependently inhibits lipopolysaccharide (LPS)-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in macrophages and that lidocaine protects mice from LPS-induced inflammation. Lidocaine interleukin 6 Mus musculus
4 Moreover, we have demonstrated that lidocaine reduces the release of TNF-alpha and IL-6 through the reduction of the expression of GLUT1 and HK2 to further suppress HIF1alpha-induced aggravation of inflammatory cascades. Lidocaine interleukin 6 Mus musculus