Title : Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.

Pub. Date : 2020 Jan 16

PMID : 31941840






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Both TAC and SIR impaired insulin secretion in fasted and/or stimulated conditions. Sirolimus insulin Homo sapiens
2 Treatment with TAC or SIR increased amyloid deposition and islet macrophages, disrupted insulin granule formation, and induced broad transcriptional dysregulation related to peptide processing, ion/calcium flux, and the extracellular matrix; however, it did not affect regulation of beta cell mass. Sirolimus insulin Homo sapiens