Title : Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats.

Pub. Date : 2020 Mar 15

PMID : 31935395






3 Functional Relationships(s)
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1 In addition, phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding protein (CREB) were enhanced with yohimbine. Yohimbine cAMP responsive element binding protein 1 Rattus norvegicus
2 In addition, phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding protein (CREB) were enhanced with yohimbine. Yohimbine cAMP responsive element binding protein 1 Rattus norvegicus
3 These results suggest that yohimbine can prevent LPS-induced sepsis associated with kidney injury by suppressing inflammatory cytokine and iNOS expression as well as enhancing IL-10 expression via ERK/CREB phosphorylation. Yohimbine cAMP responsive element binding protein 1 Rattus norvegicus