Pub. Date : 2020 Mar 31
PMID : 31904486
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All-trans retinoic acid exerts selective anti-FLT3-ITD acute myeloid leukemia efficacy through downregulating Chk1 kinase. | Tretinoin | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 2 | In this work, we report that ATRA causes fatal mitotic catastrophe in FLT3-ITD AML cells by degrading Chk1 kinase, and therefore preventing DNA damage repair. | Tretinoin | fms related receptor tyrosine kinase 3 | Homo sapiens |