Title : Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts.

Pub. Date : 2019 Dec 24

PMID : 31878245






2 Functional Relationships(s)
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1 Moreover, by suppressing miR-21-5p, STAT3, and mTOR expressions in CSC_EVs, OV re-sensitized CSCs to CDDP and suppressed OSCC tumorigenesis. ovatodiolide mechanistic target of rapamycin kinase Homo sapiens
2 In vivo, treatment with OV alone or in combination with CDDP significantly reduced the tumor sphere-forming ability and decreased EV cargos containing mTOR, PI3K, STAT3, beta-catenin, and miR-21-5p. ovatodiolide mechanistic target of rapamycin kinase Homo sapiens