Pub. Date : 2020 Aug
PMID : 31853618
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway. | salvianolic acid B | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | In the current study, Sal B significantly ameliorated myocardial I/R injury in a dose-dependent manner, ameliorated cardiac function, reduced myocardial infarction size, decreased myocardial injury marker expression, decreased inflammatory responses, reduced apoptosis, activated PI3K/Akt expression and inhibited HMGB1 expression. | salvianolic acid B | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | Overall, the present study indicated that Sal B attenuated myocardial I/R injury by activating PI3K/Akt and inhibiting the release of HMGB1 in rats. | salvianolic acid B | AKT serine/threonine kinase 1 | Rattus norvegicus |