Title : α-Ketoglutarate Modulates Macrophage Polarization Through Regulation of PPARγ Transcription and mTORC1/p70S6K Pathway to Ameliorate ALI/ARDS.

Pub. Date : 2020 Jan

PMID : 31841452






1 Functional Relationships(s)
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1 Further experiments showed that alpha-KG down-regulated the expression of M1-polarized marker genes and inhibited the activities of mammalian target of rapamycin complex 1 (mTORC1)/p70 ribosomal protein S6 kinase (p70S6K) signaling pathway in M1-polarized MH-S cells. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens