Title : A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia.

Pub. Date : 2020 Mar 2

PMID : 31770110






1 Functional Relationships(s)
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1 We show that exposure of leukemia cells to daunorubicin activated an integrated stress response-like transcriptional program to induce ABCB1 through remodeling and activation of an ATF4-bound, stress-responsive enhancer. Daunorubicin activating transcription factor 4 Homo sapiens