Title : Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib.

Pub. Date : 2019 Dec

PMID : 31675556






2 Functional Relationships(s)
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1 Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib. Curcumin mitogen-activated protein kinase kinase 7 Homo sapiens
2 Mechanistically, curcumin behaved like MEK-specific inhibitor (U0126) to enhance regorafenib-induced growth inhibition, apoptosis and autophagy in HCT 116 cells. Curcumin mitogen-activated protein kinase kinase 7 Homo sapiens