Title : The Role of Janus Kinase/Signal Transducer and Activator of Transcription Signalling on Preventing Intestinal Ischemia/Reperfusion Injury with Dexmedetomidine.

Pub. Date : 2020 May 1

PMID : 31635678






5 Functional Relationships(s)
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1 Therefore, it is reasonable to explore the associated mechanism of JAK2/STAT3 signalling in Dex treatment. Dexmedetomidine Janus kinase 2 Rattus norvegicus
2 The study purpose was to evaluate the JAK2/STAT3 signalling regulatory mechanisms of Dex in preventing I/R. Dexmedetomidine Janus kinase 2 Rattus norvegicus
3 Furthermore, phosphorylation of JAK2, STAT1 and STAT3 was affected, suggesting the involvement of activated JAK/STAT in response to Dex. Dexmedetomidine Janus kinase 2 Rattus norvegicus
4 JAK2/STAT3 activation is crucial to the diminishing effect of Dex on mesenteric I/R injury; however, the efficacy and timing of Dex administration should be considered in clinical practice. Dexmedetomidine Janus kinase 2 Rattus norvegicus
5 JAK2/STAT3 activation is crucial to the diminishing effect of Dex on mesenteric I/R injury; however, the efficacy and timing of Dex administration should be considered in clinical practice. Dexmedetomidine Janus kinase 2 Rattus norvegicus