Pub. Date : 2019
PMID : 31474712
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GDP-Bound Rab27a Dissociates from the Endocytic Machinery in a Phosphorylation-Dependent Manner after Insulin Secretion. | Guanosine Diphosphate | insulin | Homo sapiens |
| 2 | We have previously shown that in response to high concentrations of glucose, guanosine 5"-diphosphate (GDP)-bound Rab27a is recruited to the plasma membrane where IQ motif-containing guanosine 5"-triphosphatase (GTPase)-activating protein 1 (IQGAP1) is expressed, and that complex formation promotes endocytosis of secretory membranes after insulin secretion. | Guanosine Diphosphate | insulin | Homo sapiens |
| 3 | We have previously shown that in response to high concentrations of glucose, guanosine 5"-diphosphate (GDP)-bound Rab27a is recruited to the plasma membrane where IQ motif-containing guanosine 5"-triphosphatase (GTPase)-activating protein 1 (IQGAP1) is expressed, and that complex formation promotes endocytosis of secretory membranes after insulin secretion. | Guanosine Diphosphate | insulin | Homo sapiens |
| 4 | These results suggest that IQGAP1 phosphorylated by PKCepsilon promotes the dissociation of the IQGAP1-GDP-bound Rab27a complex in pancreatic beta-cells, thereby regulating endocytosis of secretory membranes following insulin secretion. | Guanosine Diphosphate | insulin | Homo sapiens |