PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31474712-0 2019 GDP-Bound Rab27a Dissociates from the Endocytic Machinery in a Phosphorylation-Dependent Manner after Insulin Secretion. Guanosine Diphosphate 0-3 insulin Homo sapiens 102-109 31474712-3 2019 We have previously shown that in response to high concentrations of glucose, guanosine 5"-diphosphate (GDP)-bound Rab27a is recruited to the plasma membrane where IQ motif-containing guanosine 5"-triphosphatase (GTPase)-activating protein 1 (IQGAP1) is expressed, and that complex formation promotes endocytosis of secretory membranes after insulin secretion. Guanosine Diphosphate 77-101 insulin Homo sapiens 341-348 31474712-3 2019 We have previously shown that in response to high concentrations of glucose, guanosine 5"-diphosphate (GDP)-bound Rab27a is recruited to the plasma membrane where IQ motif-containing guanosine 5"-triphosphatase (GTPase)-activating protein 1 (IQGAP1) is expressed, and that complex formation promotes endocytosis of secretory membranes after insulin secretion. Guanosine Diphosphate 103-106 insulin Homo sapiens 341-348 31474712-9 2019 These results suggest that IQGAP1 phosphorylated by PKCepsilon promotes the dissociation of the IQGAP1-GDP-bound Rab27a complex in pancreatic beta-cells, thereby regulating endocytosis of secretory membranes following insulin secretion. Guanosine Diphosphate 103-106 insulin Homo sapiens 218-225