Title : Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein.

Pub. Date : 2019 Dec

PMID : 31420910






2 Functional Relationships(s)
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1 Here oligomers of alpha-synuclein were prepared using the dopamine metabolite, DOPAL (3,4-dihydroxyphenyl-acetaldehyde), in the presence of guanidinium hydrochloride. Dopamine synuclein, alpha Mus musculus
2 Using isolated mouse brain mitochondria, DOPAL-oligomerized alpha-synuclein (DOS) significantly inhibited oxygen consumption rates compared with untreated, control-fibrillated, and dopamine-fibrillated synuclein, or with monomeric alpha-synuclein. Dopamine synuclein, alpha Mus musculus