Protein Name synuclein, alpha
Organism Mus musculus
Gene ID 20617
Gene Symbol


UniProt O55042 (SYUA_MOUSE)
Relationships Total Number of functionally related compound(s) : 506
Total Number of Articles : 764

synuclein, alpha

Gene Summary

Enables arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein-containing complex assembly; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Located in several cellular components, including inclusion body; neuronal cell body; and synaptic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Apr 2022]

  • alpha-synuclein
  • non-A beta component of AD amyloid
  • non-A4 component of amyloid
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