Pub. Date : 2019 Sep 27
PMID : 31402258
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We find that NTZ enhances retinoic-acid-inducible protein I (RIG-I)-like-receptor, mitochondrial antiviral signaling protein, interferon regulatory factor 3, and interferon activities and induces transcription of the antiviral phosphatase GADD34. | nitazoxanide | DExD/H-box helicase 58 | Homo sapiens |
| 2 | NTZ significantly inhibits EBOV replication in human cells through its effects on RIG-I and protein kinase R (PKR), suggesting that it counteracts EBOV VP35 protein"s ability to block RIG-I and PKR sensing of EBOV. | nitazoxanide | DExD/H-box helicase 58 | Homo sapiens |
| 3 | NTZ significantly inhibits EBOV replication in human cells through its effects on RIG-I and protein kinase R (PKR), suggesting that it counteracts EBOV VP35 protein"s ability to block RIG-I and PKR sensing of EBOV. | nitazoxanide | DExD/H-box helicase 58 | Homo sapiens |
| 4 | NTZ also inhibits a second negative-strand RNA virus, vesicular stomatitis virus (VSV), through RIG-I and GADD34, but not PKR, consistent with VSV"s distinct host innate immune evasion mechanisms. | nitazoxanide | DExD/H-box helicase 58 | Homo sapiens |