Protein Name RNA sensor RIG-I
Organism Homo sapiens
Gene ID 23586
Gene Symbol


UniProt O95786 (DDX58_HUMAN)
Relationships Total Number of functionally related compound(s) : 199
Total Number of Articles : 314

RNA sensor RIG-I

Gene Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

  • antiviral innate immune response receptor RIG-I
  • ATP-dependent RNA helicase DDX58
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
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