Pub. Date : 2019 Oct
PMID : 31387809
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decreased IL-6 induces sensitivity of hepatocellular carcinoma cells to sorafenib. | Sorafenib | interleukin 6 | Homo sapiens |
| 2 | Therefore, in the present study, we attempted to investigate the effect and mechanisms of IL-6 on sensitivity of HCC cells to sorafenib regarding the cell proliferation and apoptosis. | Sorafenib | interleukin 6 | Homo sapiens |
| 3 | Furthermore, sorafenib significantly inhibited cell proliferation, IL-6 level and activation of p-PI3K/AKT while promoted the cell apoptosis rate and Caspase3 level compared as the control group, which were further promoted by administration of si IL-6. | Sorafenib | interleukin 6 | Homo sapiens |
| 4 | Furthermore, sorafenib significantly inhibited cell proliferation, IL-6 level and activation of p-PI3K/AKT while promoted the cell apoptosis rate and Caspase3 level compared as the control group, which were further promoted by administration of si IL-6. | Sorafenib | interleukin 6 | Homo sapiens |
| 5 | Therefore, downregulating IL-6 could be a potential treatment to increase the cell sensitivity of HCC cells to sorafenib. | Sorafenib | interleukin 6 | Homo sapiens |