PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31387809-0 2019 Decreased IL-6 induces sensitivity of hepatocellular carcinoma cells to sorafenib. Sorafenib 72-81 interleukin 6 Homo sapiens 10-14 31387809-3 2019 Therefore, in the present study, we attempted to investigate the effect and mechanisms of IL-6 on sensitivity of HCC cells to sorafenib regarding the cell proliferation and apoptosis. Sorafenib 126-135 interleukin 6 Homo sapiens 90-94 31387809-7 2019 Furthermore, sorafenib significantly inhibited cell proliferation, IL-6 level and activation of p-PI3K/AKT while promoted the cell apoptosis rate and Caspase3 level compared as the control group, which were further promoted by administration of si IL-6. Sorafenib 13-22 interleukin 6 Homo sapiens 67-71 31387809-7 2019 Furthermore, sorafenib significantly inhibited cell proliferation, IL-6 level and activation of p-PI3K/AKT while promoted the cell apoptosis rate and Caspase3 level compared as the control group, which were further promoted by administration of si IL-6. Sorafenib 13-22 interleukin 6 Homo sapiens 248-252 31387809-8 2019 Therefore, downregulating IL-6 could be a potential treatment to increase the cell sensitivity of HCC cells to sorafenib. Sorafenib 111-120 interleukin 6 Homo sapiens 26-30