Pub. Date : 2019 Oct 1
PMID : 31381904
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The involvement of lipid raft pathway in suppression of TGFbeta-mediated metastasis by tolfenamic acid in hepatocellular carcinoma cells. | tolfenamic acid | transforming growth factor alpha | Mus musculus |
| 2 | Herein, we investigated the effect of TA on TGFbeta-mediated pro-metastatic activity and the underlying mechanisms in hepatocellular carcinoma (HCC). | tolfenamic acid | transforming growth factor alpha | Mus musculus |
| 3 | As a result, TA suppresses TGFbeta-induced migration and glycolysis in HCC cells, which is accompanied with reduced Smad phosphorylation and subsequent nuclear transcription activity. | tolfenamic acid | transforming growth factor alpha | Mus musculus |
| 4 | Mechanistically, TA promotes lipid raft-caveolar internalization pathway of TGFbeta receptor, therefore leading to its rapid turnover. | tolfenamic acid | transforming growth factor alpha | Mus musculus |
| 5 | Consistently, TA inhibits constitutively active TGFbeta type I receptor induced Smad phosphorylation and EMT markers, whereas ectopic expression of TGFbeta type II receptor could partially rescue TGFbeta-mediated Smad2 phosphorylation and downstream genes expression in the presence of TA. | tolfenamic acid | transforming growth factor alpha | Mus musculus |
| 6 | Our study suggests TA could activate lipid raft pathway and modulate TGFbeta mediated metastasis, implicating the potential application of TA as a modulator of tumor microenvironment in HCC. | tolfenamic acid | transforming growth factor alpha | Mus musculus |