PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31381904-0	2019	The involvement of lipid raft pathway in suppression of TGFbeta-mediated metastasis by tolfenamic acid in hepatocellular carcinoma cells.	tolfenamic acid	87-102	transforming growth factor alpha	Mus musculus	56-63	
31381904-3	2019	Herein, we investigated the effect of TA on TGFbeta-mediated pro-metastatic activity and the underlying mechanisms in hepatocellular carcinoma (HCC).	tolfenamic acid	38-40	transforming growth factor alpha	Mus musculus	44-51	
31381904-4	2019	As a result, TA suppresses TGFbeta-induced migration and glycolysis in HCC cells, which is accompanied with reduced Smad phosphorylation and subsequent nuclear transcription activity.	tolfenamic acid	13-15	transforming growth factor alpha	Mus musculus	27-34	
31381904-5	2019	Mechanistically, TA promotes lipid raft-caveolar internalization pathway of TGFbeta receptor, therefore leading to its rapid turnover.	tolfenamic acid	17-19	transforming growth factor alpha	Mus musculus	76-83	
31381904-6	2019	Consistently, TA inhibits constitutively active TGFbeta type I receptor induced Smad phosphorylation and EMT markers, whereas ectopic expression of TGFbeta type II receptor could partially rescue TGFbeta-mediated Smad2 phosphorylation and downstream genes expression in the presence of TA.	tolfenamic acid	14-16	transforming growth factor alpha	Mus musculus	48-55	
31381904-8	2019	Our study suggests TA could activate lipid raft pathway and modulate TGFbeta mediated metastasis, implicating the potential application of TA as a modulator of tumor microenvironment in HCC.	tolfenamic acid	19-21	transforming growth factor alpha	Mus musculus	69-76