Protein Name transforming growth factor alpha
Organism Mus musculus
Gene ID 21802
Gene Symbol


UniProt P48030 (TGFA_MOUSE), Q545E4 (Q545E4_MOUSE)
Relationships Total Number of functionally related compound(s) : 542
Total Number of Articles : 680

transforming growth factor alpha

Gene Summary

This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein binds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015]

  • protransforming growth factor alpha
  • wa-1
  • wa1
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