Pub. Date : 2019 Dec
PMID : 31374317
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bisphenol A affects estradiol metabolism by targeting CYP1A1 and CYP19A1 in human placental JEG-3 cells. | Estradiol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | Additionally, by lentiviral transduction, we determined that estradiol level of JEG-3 cells over-expressing CYP1A1 gene was notably decreased and the decrease was of 84.9% compared to the control. | Estradiol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | In summary, our research clearly showed that BPA alters JEG-3 estradiol synthesis and catabolism due to its action on CYP1A1 and CYP19A1 protein levels and may interfere with the normal process of placenta formation and embryonic development during early pregnancy. | Estradiol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |