Pub. Date : 2019 Jul 22
PMID : 31331356
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here the authors intended to identify the role of HMGB1 in Hank"s balanced salt solution (HBSS)-induced autophagy, explore NIS protein degradation through a autophagy-lysosome pathway in thyroid cancer cells and elucidate the possible molecular mechanisms. | hbss | high mobility group box 1 | Homo sapiens |
| 2 | RESULTS: HMGB1 was a critical regulator of autophagy-mediated NIS degradation in HBSS-treated FTC-133/TPC-1 cells. | hbss | high mobility group box 1 | Homo sapiens |
| 3 | HMGB1-knockdown dramatically suppressed autophagy, NIS degradation and boosted iodide uptake in HBSS-treated cells. | hbss | high mobility group box 1 | Homo sapiens |
| 4 | Moreover, HBSS enhanced ROS-sustained autophagy and promoted the cytosolic translocation of HMGB1. | hbss | high mobility group box 1 | Homo sapiens |