Pub. Date : 2019 Oct 10
PMID : 31306741
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro, corticosterone increased GR and HDAC7 whereas reduced the H3K9ac level of KLF4 and KLF4/Nephrin expression. | Corticosterone | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
| 2 | KLF4 over-expression reversed the reduction of Nephrin expression, knockdown of HDAC7 and GR antagonist RU486 partially reversed the inhibitory effects of corticosterone on H3K9ac level and KLF4 expression. | Corticosterone | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
| 3 | In conclusion, PCE caused podocyte developmental toxicity in male offspring, which was associated with corticosterone-induced low-functional programming of KLF4 through GR/HDAC7/H3K9ac pathway. | Corticosterone | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |