Title : Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity.

Pub. Date : 2019 Jun 18

PMID : 31216465






1 Functional Relationships(s)
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1 Our data identify a role of PARP-1 in controlling ROS levels upon EGFR TKI treatment, with potentially broad implications for therapeutic targeting of the mechanisms that govern the survival of oncogene-driven cancer cells. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens