Pub. Date : 2019 Aug 28
PMID : 31204637
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sodium butyrate (NaB) has been shown to alleviate oxidative stress and insulin resistance, yet how Nrf2 is involved in the action of NaB remains unclear. | nab | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | Additionally, the insulin signalling pathway in the liver was activated by NaB, associated with significant activation of Nrf2, superoxide dismutase and glutathione. | nab | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | Furthermore, hepatic up-regulation of Nrf2 in NaB-treated rats was associated with reduced protein content of histone deacetylase 1 and increased histone H3 acetyl K9 (H3K9Ac) modification on the Nrf2 promoter. | nab | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 4 | Furthermore, hepatic up-regulation of Nrf2 in NaB-treated rats was associated with reduced protein content of histone deacetylase 1 and increased histone H3 acetyl K9 (H3K9Ac) modification on the Nrf2 promoter. | nab | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 5 | The actions of NaB were completely abolished when Nrf2 was knocked down in vitro. | nab | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 6 | Taken together, NaB acts as a histone deacetylase inhibitor to up-regulate Nrf2 expression with enhanced H3K9Ac modification on its promoter. | nab | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 7 | NaB-induced Nrf2 activation stimulates transcription of downstream antioxidant enzymes, thus contributing to the amelioration of high-fat diet-induced oxidative stress and insulin resistance. | nab | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |