Pub. Date : 2019 Jun 7
PMID : 31175267
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+-Sirt1 signaling. | NAD | nicotinamide phosphoribosyltransferase | Rattus norvegicus |
| 2 | Previously, we found that MSC natural senescence is accompanied by altered intracellular nicotinamide adenine dinucleotide (NAD+) metabolism, in which Nampt plays a key role. | NAD | nicotinamide phosphoribosyltransferase | Rattus norvegicus |
| 3 | Previously, we found that MSC natural senescence is accompanied by altered intracellular nicotinamide adenine dinucleotide (NAD+) metabolism, in which Nampt plays a key role. | NAD | nicotinamide phosphoribosyltransferase | Rattus norvegicus |
| 4 | Further, Nampt inhibition resulted in reduced intracellular NAD+ content, NAD+/NADH ratio, and Sirt1 activity, whereas overexpression had the opposite effects. | NAD | nicotinamide phosphoribosyltransferase | Rattus norvegicus |
| 5 | Further, Nampt inhibition resulted in reduced intracellular NAD+ content, NAD+/NADH ratio, and Sirt1 activity, whereas overexpression had the opposite effects. | NAD | nicotinamide phosphoribosyltransferase | Rattus norvegicus |
| 6 | Further, Nampt inhibition resulted in reduced intracellular NAD+ content, NAD+/NADH ratio, and Sirt1 activity, whereas overexpression had the opposite effects. | NAD | nicotinamide phosphoribosyltransferase | Rattus norvegicus |
| 7 | Thus, Nampt suppresses MSC senescence via mediating NAD+-Sirt1 signaling. | NAD | nicotinamide phosphoribosyltransferase | Rattus norvegicus |