PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31175267-0 2019 Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+-Sirt1 signaling. NAD 111-115 nicotinamide phosphoribosyltransferase Rattus norvegicus 0-38 31175267-2 2019 Previously, we found that MSC natural senescence is accompanied by altered intracellular nicotinamide adenine dinucleotide (NAD+) metabolism, in which Nampt plays a key role. NAD 89-122 nicotinamide phosphoribosyltransferase Rattus norvegicus 151-156 31175267-2 2019 Previously, we found that MSC natural senescence is accompanied by altered intracellular nicotinamide adenine dinucleotide (NAD+) metabolism, in which Nampt plays a key role. NAD 124-128 nicotinamide phosphoribosyltransferase Rattus norvegicus 151-156 31175267-7 2019 Further, Nampt inhibition resulted in reduced intracellular NAD+ content, NAD+/NADH ratio, and Sirt1 activity, whereas overexpression had the opposite effects. NAD 60-64 nicotinamide phosphoribosyltransferase Rattus norvegicus 9-14 31175267-7 2019 Further, Nampt inhibition resulted in reduced intracellular NAD+ content, NAD+/NADH ratio, and Sirt1 activity, whereas overexpression had the opposite effects. NAD 74-78 nicotinamide phosphoribosyltransferase Rattus norvegicus 9-14 31175267-7 2019 Further, Nampt inhibition resulted in reduced intracellular NAD+ content, NAD+/NADH ratio, and Sirt1 activity, whereas overexpression had the opposite effects. NAD 79-83 nicotinamide phosphoribosyltransferase Rattus norvegicus 9-14 31175267-9 2019 Thus, Nampt suppresses MSC senescence via mediating NAD+-Sirt1 signaling. NAD 52-56 nicotinamide phosphoribosyltransferase Rattus norvegicus 6-11