Title : C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6.

Pub. Date : 2019

PMID : 31123462






2 Functional Relationships(s)
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1 Results: Here, we report on a form of TRAF6 ubiquitination that is mediated by c-Cbl, leading to the formation of lysine 48-linked polyubiquitin chains. Lysine Cbl proto-oncogene Homo sapiens
2 Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma. Lysine Cbl proto-oncogene Homo sapiens