Protein Name Cbl proto-oncogene
Organism Homo sapiens
Gene ID 867
Gene Symbol


UniProt P22681 (CBL_HUMAN)
Relationships Total Number of functionally related compound(s) : 449
Total Number of Articles : 644

Cbl proto-oncogene

Gene Summary

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]

  • E3 ubiquitin-protein ligase CBL
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence
  • Cbl proto-oncogene, E3 ubiquitin protein ligase
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