Pub. Date : 2019 Jul 3
PMID : 31058500
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EF-Tu alternates between GTP- and GDP-bound conformations during its functional cycle, representing the "on" and "off" states, respectively. | Guanosine Diphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 2 | Additionally, molecular dynamics (MD) simulations indicate that enthalpic stabilization of GDP binding compared to GTP binding originates in the backbone hydrogen bonding network of EF-Tu. | Guanosine Diphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 3 | In contrast, binding of GTP to EF-Tu is entropically driven by the liberation of bound water during the GDP- to GTP-bound transition. | Guanosine Diphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 4 | GDP binding to the apo conformation of EF-Tu is both enthalpically and entropically favored, a feature unique among translational GTPases. | Guanosine Diphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |