Title : Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib.

Pub. Date : 2019 Jun

PMID : 31002342






1 Functional Relationships(s)
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1 Mechanistically, MLN4924 enhanced the antitumor activity of sorafenib in HCC cells via upregulation of cullin-RING E3 ubiquitin ligase (CRL)/Skp1-Cullin1-F box (SCF) E3 ubiquitin ligase substrates p21, p27, Deptor and IkappaBalpha. Sorafenib NFKB inhibitor alpha Homo sapiens