Protein Name NFKB inhibitor alpha
Organism Homo sapiens
Gene ID 4792
Gene Symbol


UniProt P25963 (IKBA_HUMAN)
Relationships Total Number of functionally related compound(s) : 1043
Total Number of Articles : 1821

NFKB inhibitor alpha

Gene Summary

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

  • NF-kappa-B inhibitor alpha
  • I-kappa-B-alpha
  • IkappaBalpha
Click to show/hide the synonyms