| Protein Name | NFKB inhibitor alpha |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4792 |
| Gene Symbol | NFKBIA |
| UniProt | P25963 (IKBA_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
1043
Total Number of Articles : 1821 |
Description |
NFKB inhibitor alpha |
| Gene Summary |
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011] |
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| Properties | |