Pub. Date : 2019 Jun 4
PMID : 30981500
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PFKFB3/HIF-1alpha feedback loop modulates sorafenib resistance in hepatocellular carcinoma cells. | Sorafenib | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Homo sapiens |
| 2 | Thereafter, the expression of PFKFB3 was elevated in hepatocellular carcinoma cell after sorafenib treatment, which was confirmed in Gene Expression Omnibus (GEO) datasets. | Sorafenib | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Homo sapiens |
| 3 | As predicted, the overexpression of PFKFB3 significantly enhanced HCC cells resistance to sorafenib by decreasing expression of the apoptosis-related molecules as well as apoptotic cells. | Sorafenib | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Homo sapiens |
| 4 | Further mechanistic study uncovered that HIF-1alpha deficiency impaired sorafenib resistance induced by PFKFB3 overexpression in HCC cells. | Sorafenib | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Homo sapiens |
| 5 | To conclude, here we reveal a previously unrecognised positive feedback loop exists between PFKFB3 and HIF-1alpha and a novel HIF-1alpha-dependent role of PFKFB3 in regulating sorafenib resistance in HCC cells, suggesting new potential therapeutic targets for HCC treatment. | Sorafenib | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Homo sapiens |