| Protein Name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5209 |
| Gene Symbol | PFKFB3 |
| UniProt | Q16875 (F263_HUMAN), B7Z8A0 (B7Z8A0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
146
Total Number of Articles : 194 |
Description |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| Gene Summary |
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] |
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