Pub. Date : 2019 Jun 17
PMID : 30950278
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Highly Variable Expression of CYP1A1 in Human Liver and Impact on Pharmacokinetics of Riociguat and Granisetron in Humans. | Granisetron | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | Together with the high selectivity and especially the high metabolic efficiency of CYP1A1 shown for granisetron and riociguat, it is demonstrated that CYP1A1 plays an important role in the metabolic clearance of these drugs and is responsible for the clinically observed interindividual variability in their pharmacokinetics. | Granisetron | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Together with the high selectivity and especially the high metabolic efficiency of CYP1A1 shown for granisetron and riociguat, it is demonstrated that CYP1A1 plays an important role in the metabolic clearance of these drugs and is responsible for the clinically observed interindividual variability in their pharmacokinetics. | Granisetron | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |