Title : Biological Evaluation and Molecular Dynamics Simulation of Chalcone Derivatives as Epidermal Growth Factor-Tyrosine Kinase Inhibitors.

Pub. Date : 2019 Mar 20

PMID : 30897725






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Only three chalcones (1c, 2a and 3e) had an inhibitory activity against EGFR-TK with a relative inhibition percentage that was close to the approved drug, erlotinib. Chalcones epidermal growth factor receptor Homo sapiens
2 From the above information, as well as ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties, all three chalcones could serve as lead compounds for the development of EGFR-TK inhibitors. Chalcones epidermal growth factor receptor Homo sapiens