Title : Regulation of intracellular pH by electrogenic Na+/HCO3- co-transporters in embryonic neural stem cell-derived radial glia-like cells.

Pub. Date : 2019 Jun 1

PMID : 30890468






4 Functional Relationships(s)
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1 However, when extracellular calcium was removed, an instant depolarization and recovery of the pHi, back to normal levels, took place. Calcium glucose-6-phosphate isomerase 1 Mus musculus
2 Immunostaining and PCR data, showed that NBCe1 (SLC4A4) and NBCn1 (SLC4A7) were expressed in the cell population and that the pHi recovery in the radial glial-like cells after calcium removal was mediated mainly by the electrogenic sodium bicarbonate transporter NBCe1 (SLC4A4). Calcium glucose-6-phosphate isomerase 1 Mus musculus
3 Our results indicate that extracellular calcium might hamper pHi regulation and Na/HCO3 cotransporter activity in a brain injury microenvironment. Calcium glucose-6-phosphate isomerase 1 Mus musculus
4 Our findings show that the NBC-type transporters are the main pHi regulating systems prevailing in glia-like progenitor cells and that these calcium sensitive transporters are important for neuronal progenitor cell proliferation, survival and neural stem cell differentiation. Calcium glucose-6-phosphate isomerase 1 Mus musculus