| Protein Name | glucose-6-phosphate isomerase 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 14751 |
| Gene Symbol | Gpi1 |
| UniProt | P06745 (G6PI_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
272
Total Number of Articles : 232 |
Description |
glucose-6-phosphate isomerase 1 |
| Gene Summary |
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016] |
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| Properties | |