Protein Name glucose-6-phosphate isomerase 1
Organism Mus musculus
Gene ID 14751
Gene Symbol


UniProt P06745 (G6PI_MOUSE)
Relationships Total Number of functionally related compound(s) : 272
Total Number of Articles : 232

glucose-6-phosphate isomerase 1

Gene Summary

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016]

  • glucose-6-phosphate isomerase
  • autocrine motility factor
  • glucose phosphate isomerase 1 complex
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